Tick ThaNK | Tick-borne encephalitis Targeted by Human Active NK cells

Summary
The aim of this project is to determine the role of natural killer (NK) cells, effector players of the innate immune system that target virally infected cells and tumor cells, in the infectious disease Tick-borne encephalitis (TBE). By elucidating their function either in enhancing or suppressing the disease in two different compartments, central nervous system (CNS) and peripheral blood, we seek to generate knowledge that will provide new insights into innate immunity that could lead to novel strategies to improve treatments for infectious diseases.
This project is intended to take place mainly in the Center of Infectious Medicine from the Department of Medicine at Karolinska Institutet (KI) in Stockholm. To complement the scientific training proposed, a secondment of two months will be carried out at the VU University Medical Center in Amsterdam, Netherlands.
Overall, the goal of the present application is to support the restart of the scientific formation of the applicant, who has made a 2-year career break due to maternity leave. The short-term objective of the current study is to provide training of the researcher in advanced cellular characterization, labeling, and bio-imaging techniques, synergistically with trans-European mobility, reinforcing her scientific, managerial and leadership qualities. A mid-term objective is the progress of the researcher’s career in science and the broadening of her scientific horizons, and a long-term aim is the Fellow’s setting as an independent investigator.
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More information & hyperlinks
Web resources: https://cordis.europa.eu/project/id/794453
Start date: 01-01-2019
End date: 03-03-2021
Total budget - Public funding: 185 857,20 Euro - 185 857,00 Euro
Cordis data

Original description

The aim of this project is to determine the role of natural killer (NK) cells, effector players of the innate immune system that target virally infected cells and tumor cells, in the infectious disease Tick-borne encephalitis (TBE). By elucidating their function either in enhancing or suppressing the disease in two different compartments, central nervous system (CNS) and peripheral blood, we seek to generate knowledge that will provide new insights into innate immunity that could lead to novel strategies to improve treatments for infectious diseases.
This project is intended to take place mainly in the Center of Infectious Medicine from the Department of Medicine at Karolinska Institutet (KI) in Stockholm. To complement the scientific training proposed, a secondment of two months will be carried out at the VU University Medical Center in Amsterdam, Netherlands.
Overall, the goal of the present application is to support the restart of the scientific formation of the applicant, who has made a 2-year career break due to maternity leave. The short-term objective of the current study is to provide training of the researcher in advanced cellular characterization, labeling, and bio-imaging techniques, synergistically with trans-European mobility, reinforcing her scientific, managerial and leadership qualities. A mid-term objective is the progress of the researcher’s career in science and the broadening of her scientific horizons, and a long-term aim is the Fellow’s setting as an independent investigator.

Status

CLOSED

Call topic

MSCA-IF-2017

Update Date

28-04-2024
Geographical location(s)
Structured mapping
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EU-Programme-Call
Horizon 2020
H2020-EU.1. EXCELLENT SCIENCE
H2020-EU.1.3. EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions (MSCA)
H2020-EU.1.3.2. Nurturing excellence by means of cross-border and cross-sector mobility
H2020-MSCA-IF-2017
MSCA-IF-2017