Histotype Px | Precision biomarker based on digital pathology and artificial intelligence to guide fast and cost-effective personalized treatment decision support for colorectal cancer patients

Summary
There is consensus in the oncology community that there is a large need for personalized cancer treatment decisions as patients suffer from large-scale overtreatment. Up to 90% of patients receiving adjuvant chemotherapy have no effect, many suffer severe side effects. DoMore Diagnostics (DoMore Dx) delivers pioneering diagnostics software that enables personalized cancer treatment in a simple and cost-efficient way. We provide deep learning algorithms applied to cancer tissue whole slide images (WSI) in the adjuvant chemotherapy setting. With end-to-end deep learning we have taken a completely new approach to this challenge. Our test can be run in local labs with digital pathology equipment and does not consume any tissue. DoMore Dx is personalized medicine made simple.
In CRC, our test can stratify patients into low, intermediate, or high risk with a hazard ratio >10. This information can be used to take up to 250,000 patients out of chemotherapy and save 4 billion EUR globally every year.
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More information & hyperlinks
Web resources: https://cordis.europa.eu/project/id/101161792
Start date: 01-06-2024
End date: 31-05-2026
Total budget - Public funding: 5 326 967,50 Euro - 2 499 999,00 Euro
Cordis data

Original description

There is consensus in the oncology community that there is a large need for personalized cancer treatment decisions as patients suffer from large-scale overtreatment. Up to 90% of patients receiving adjuvant chemotherapy have no effect, many suffer severe side effects. DoMore Diagnostics (DoMore Dx) delivers pioneering diagnostics software that enables personalized cancer treatment in a simple and cost-efficient way. We provide deep learning algorithms applied to cancer tissue whole slide images (WSI) in the adjuvant chemotherapy setting. With end-to-end deep learning we have taken a completely new approach to this challenge. Our test can be run in local labs with digital pathology equipment and does not consume any tissue. DoMore Dx is personalized medicine made simple.
In CRC, our test can stratify patients into low, intermediate, or high risk with a hazard ratio >10. This information can be used to take up to 250,000 patients out of chemotherapy and save 4 billion EUR globally every year.

Status

SIGNED

Call topic

HORIZON-EIC-2023-ACCELERATORCHALLENGES-01

Update Date

01-07-2025
Geographical location(s)
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EU-Programme-Call
Horizon Europe
HORIZON.3 Innovative Europe
HORIZON.3.1 The European Innovation Council (EIC)
HORIZON.3.1.0 Cross-cutting call topics
HORIZON-EIC-2023-ACCELERATOR-01
HORIZON-EIC-2023-ACCELERATORCHALLENGES-01 EIC Accelerator Challenge: Novel biomarker-based assays to guide personalised cancer treatment