Summary
Every second, millions of cells go through mitosis in the human body, a process dividing the cells and their genetic content. In eukaryotic cells, a cytoskeletal structure named the spindle apparatus is responsible for physically separating the duplicated chromosomes. The self-organization of filaments (microtubules) and associated molecular motor proteins shape this structure. For decades, the dynamics of active cytoskeletal matter have been investigated both in vivo and in vitro. However, a comprehensive quantitative understanding of the dynamics of the constituents and their energy budget remains elusive.
This action aims to investigate the non-equilibrium dynamics of contractile self-organizing active cytoskeletal material through energy and order quantification and to establish a field-based model to describe energetics and dynamics in three dimensions.
This action aims to investigate the non-equilibrium dynamics of contractile self-organizing active cytoskeletal material through energy and order quantification and to establish a field-based model to describe energetics and dynamics in three dimensions.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/101153693 |
| Start date: | 01-10-2024 |
| End date: | 31-10-2027 |
| Total budget - Public funding: | - 289 407,00 Euro |
Cordis data
Original description
Every second, millions of cells go through mitosis in the human body, a process dividing the cells and their genetic content. In eukaryotic cells, a cytoskeletal structure named the spindle apparatus is responsible for physically separating the duplicated chromosomes. The self-organization of filaments (microtubules) and associated molecular motor proteins shape this structure. For decades, the dynamics of active cytoskeletal matter have been investigated both in vivo and in vitro. However, a comprehensive quantitative understanding of the dynamics of the constituents and their energy budget remains elusive.This action aims to investigate the non-equilibrium dynamics of contractile self-organizing active cytoskeletal material through energy and order quantification and to establish a field-based model to describe energetics and dynamics in three dimensions.
Status
SIGNEDCall topic
HORIZON-MSCA-2023-PF-01-01Update Date
29-10-2025
Geographical location(s)
