Summary
The increase of anthropogenic chemicals released by human activities poses a growing threat to natural and man-made environments. Characterizing the mixture of chemicals that an individual encounters throughout lifetime, namely exposome, is a complex analytical task that is only partially fulfilled by current state-of-the-art methods. Non-targeted analysis approaches based on liquid reversed-phase chromatography hyphenated with high-resolution mass spectrometry restrict the detectable exposome chemical space to medium-to-low polarity chemicals. The BEspace project seeks to untangle sample complexity and expand the detectable exposome through advanced separation approaches, combined in a two-dimensional fashion and hyphenated with high-resolution mass spectrometers. On this basis, it shall boost the profiling of chemicals of environmental concern in relevant exposome matrices like environmental and treated water samples, thanks to the collaboration with KWR Water Research Institute. Even though two-dimensional liquid chromatography approaches provide increased separation selectivity and capacity, boosting the detectable chemical space coverage of the aqueous samples, their application in exposomics is limited. The complex two-dimensional data structure and the lack of standardized procedures hamper the exposome chemical identification, requiring the implementation of composite cheminformatics tools. Therefore, BEspace will develop advanced wet and dry lab analytical platforms to expand the detectable chemical space of the aqueous compartment. Large-scale quali-quantitative exposomics datasets will be project final outputs, providing cutting-edge data to be publicly shared to enrich present databases and to develop novel risk assessment approaches. The implicit multidisciplinarity of the project grants multiple-way knowledge transfer among the host institution, the researcher, and the associate partner.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/101150312 |
| Start date: | 01-11-2024 |
| End date: | 31-10-2026 |
| Total budget - Public funding: | - 187 624,00 Euro |
Cordis data
Original description
The increase of anthropogenic chemicals released by human activities poses a growing threat to natural and man-made environments. Characterizing the mixture of chemicals that an individual encounters throughout lifetime, namely exposome, is a complex analytical task that is only partially fulfilled by current state-of-the-art methods. Non-targeted analysis approaches based on liquid reversed-phase chromatography hyphenated with high-resolution mass spectrometry restrict the detectable exposome chemical space to medium-to-low polarity chemicals. The BEspace project seeks to untangle sample complexity and expand the detectable exposome through advanced separation approaches, combined in a two-dimensional fashion and hyphenated with high-resolution mass spectrometers. On this basis, it shall boost the profiling of chemicals of environmental concern in relevant exposome matrices like environmental and treated water samples, thanks to the collaboration with KWR Water Research Institute. Even though two-dimensional liquid chromatography approaches provide increased separation selectivity and capacity, boosting the detectable chemical space coverage of the aqueous samples, their application in exposomics is limited. The complex two-dimensional data structure and the lack of standardized procedures hamper the exposome chemical identification, requiring the implementation of composite cheminformatics tools. Therefore, BEspace will develop advanced wet and dry lab analytical platforms to expand the detectable chemical space of the aqueous compartment. Large-scale quali-quantitative exposomics datasets will be project final outputs, providing cutting-edge data to be publicly shared to enrich present databases and to develop novel risk assessment approaches. The implicit multidisciplinarity of the project grants multiple-way knowledge transfer among the host institution, the researcher, and the associate partner.Status
SIGNEDCall topic
HORIZON-MSCA-2023-PF-01-01Update Date
01-05-2025
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