Summary
ANSES, in cooperation with RIVM, will define exposure scenarios. The scenarios will address the cumulative assessment groups defined by EFSA and based on data organized in task 5.1. ANSES, RIVM, CZU, MATIS, Ugent, HSE, NIJZ, URV, BPI and Ministry of Health of the Republic Cyprus will divide the exposure scenarios and chemicals of interest. Exposure calculations will be performed using probabilistic methods already implemented in the ACROPOLIS-IT tool, which is part of the EuroMix web-based model toolbox. Depending on the nature of the risk (acute or chronic), exposure will be estimated at the person-day or person level, respectively. Acute exposure will be calculated by Monte Carlo integration of consumption and concentration distributions. Chronic exposure will be calculated using the Logistic Normal-Normal (LNN) model. NIJZ, BPI and Ministry of Health of the Republic Cyprus will search for processing factors in the open literature and/or Draft Assessment Reports. The calculations will account for processing effects and unit variability as far as practically possible. This will result in a scientific article ready for submission on cumulative assessment of mixtures of several chemical classes (deliverable 5.3).
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