Scientific article ready for submission describing the in vitro testing strategy for developmental/endocrine toxicity

The most pertinent in vitro tests as selected in task 3.1 will be used to test a broader range of chemicals selected within WP2 and WP5. . Mixtures of chemicals that are listed in CAG as established by the PPR panel of EFSA for pesticides will be chosen, as well as mixtures of pesticides and non-pesticides, and these will be tested with the battery of in vitro assays as well as with the CAG-specific PCR arrays. The dose-response effects of the individual chemicals (similar and dissimilar MoA) will be compared to those of the mixtures in order to determine whether the mixtures are behaving according to the CA or IA model (WP4). The outcome of the tests will be used for the selection of a limited number of index compounds to be tested as single chemicals and as mixtures in an in-vivo study for the validation of the in-vitro results (WP4.3; M3.2). The results of Task 3.3 will be compared with the outcome of the animal studies conducted within WP4. The results for endocrine/developmental will be described in a scientific articles ready for submission (Deliverable 3.3) which will be ready in M42.