Summary
The most pertinent in vitro tests as selected in task 31 will be used to test a broader range of chemicals selected within WP2 and WP5 Mixtures of chemicals that are listed in CAG as established by the PPR panel of EFSA for pesticides will be chosen as well as mixtures of pesticides and nonpesticides and these will be tested with the battery of in vitro assays as well as with the CAGspecific PCR arrays The doseresponse effects of the individual chemicals similar and dissimilar MoA will be compared to those of the mixtures in order to determine whether the mixtures are behaving according to the CA or IA model WP4The outcome of the tests will be used for the selection of a limited number of index compounds to be tested as single chemicals and as mixtures in an invivo study for the validation of the invitro results WP43 M32 The results of Task 33 will be compared with the outcome of the animal studies conducted within WP4 The results for liver toxicty wiill be described in scientific article ready for submission Deliverable 32 which will be ready in M42
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