Report on the relationship of early-life stressors with fetal and childhood brain developmental outcomes and the extent to which these mediate associations of early-life exposures with mental health and psychopathology life course trajectories

We will study brain development from the fetal period and childhood onwards by means of advanced imaging studies including repeated fetal ultrasound and childhood MRI brain studies We will first study the role of brain developmental adaptations in fetal life or childhood Generation R Generation R Next INMA ALSPAC BIB NFBC1986 RAINE and subsequently try to replicate the findings in adults NFBC1966 This deliverable will provide insights to the role of developmental structural and functional brain developmental adaptations in the relationships between earlylife stressors and mental health trajectories