Development and application of optimised polygenic risk scores

A report on the development and application of optimised polygenic risk scores We will focus on the development and implementation of methods to generate polygenic risk scores for traits of mutual interest and to use them both for trait prediction and causal inference in a Mendelian randomisation framework The methods developed will generate novel biological and translational insights including polygenic risk scores for medically relevant traits such as type 2 diabetes and coronary artery disease that are optimised for use across multiple samples andor populations