Periodic Reporting for period 4 - PRION2020 (Function and malfunction of the prion protein)

Transmissible spongiform encephalopathies (TSE) are caused by the ordered aggregation of PrPC into prions consisting of PrPSc. Similar pathogenetic principles operate in Alzheimer’s and Parkinson’s disease, and a growing list of further diseases. Familial TSE are...