Periodic Reporting for period 4 - IL7sigNETure (IL-7/IL-7R signaling networks in health and malignancy)

Interleukin 7 (IL7) and its receptor (IL7R) are essential for normal T-cell development and function. However, they can also promote autoimmunity, chronic inflammation and cancer. We and others have shown that patients with T-cell acute lymphoblastic leukemia (T-ALL), an...