Periodic Reporting for period 4 - HEPASPHER (Mimicking liver disease and regeneration in vitro for drug development and liver transplantation)

Problem and importance. A serious and important cause of liver damage is adverse drug reactions (ADRs). It is estimated that adverse drug reactions cost as much as the drug treatment itself, cause 4% of new chemical agents to be withdrawn from the market and are the 4th to 5th...