Periodic Reporting for period 1 - CRISPR-GQ (Identifying the Capabilities and Limitations of CRISPR in Targeting G-quadruplex Forming Sequences: From Target Recognition to Gene Expression Regulation)

Despite being a bacterial immune response against phage attacks, Clustered Regularly Interspaced Palindromic Repeats (CRISPR) and associated proteins (Cas) have provided unprecedented control on genome editing at both cellular and organismal levels. Due to its simple targeting...