Periodic Reporting for period 1 - REACT (Uncovering the role of cis genetic elements in antigenic variation of Plasmodium falciparum using the CRISPR-Cas9 genome editing technology)

The objectives of the project REACT were focused on the use of CRISPR-Cas9 technology to find out the role of cis-genetic elements on the var gene family expression in Plasmodium falciparum. Direct deletion of such elements proved to be challenging, mainly due to the high...