Periodic Reporting for period 1 - NOVENA (Exploiting an unusual polyketide chain release mechanism for production of novel enacyloxin antibiotic analogues)

Enacyloxin IIa is a polyketide antibiotic with activity against Gram-positive and Gram-negative bacteria that targets ribosomal elongation factor Tu. It has recently been identified as metabolite of Burkholderia ambifaria and shown to have clinically-relevant activity against...