Periodic Reporting for period 1 - NeuroFreezing (Biophysical Properties of the Neuronal Cytosol and their Dynamics upon Nutrient Starvation, Aging, and in Neurodegenerative Diseases.)

Neurodegenerative polyglutamine (polyQ) expansion disorders such as Huntington’s disease (HD) are devastating, progressive and ultimately fatal diseases with no effective treatment or cure. The molecular hallmark of the diseases is an age-dependent, neurotoxic aggregation of...