Report on differences in DNA methylation loci that mediate the associations of early-life exposures with cardio-metabolic risk factors and disease

We will identify DNA methylation loci that mediate the associations of individual earlylife stressors and the integrated earlylife exposome with cardiometabolic risk factor trajectories and disease We will use data from studies that have epigenomewide data on DNA methylation which can be used for epigenomewide association studies EWAS metaanalyses to identify epigenetic markers associated with cardiometabolic outcomes