Periodic Reporting for period 1 - QDHassay (In vitro and In-cell characterization of Quadruplex-duplex hybrids: conformation, folding, and recognition by drug-like ligand molecule)

The formation of secondary structures in nucleic acids affects regulatory processes and diseases. In addition to the Watson-Crick duplex, guanine-rich sequences can form G-quadruplexes (G4), important targets in structural biology. The G-quadruplex-duplex hybrid (QDH) combines...