Periodic Reporting for period 1 - STOP-FIX-GO (Mechanisms at the interface of DNA damage repair and transcription)

Bulky DNA lesions are a major obstacle during gene transcription by RNA polymerase II enzymes (RNAPII). The stalling of RNAPII at DNA lesions triggers a genome-wide transcriptional arrest. Transcription-coupled repair (TCR) is a specialized DNA repair pathway that selectively...