TNF-<i>α</i>disrupts the malate-aspartate shuttle, driving metabolic rewiring in iPSC-derived enteric neural lineages from Parkinson’s Disease patients

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Authors: Bruno Ghirotto; Luís Eduardo Gonçalves; Vivien Ruder; Christina James; Elizaveta Gerasimova; Tania Rizo; Holger Wend; Michaela Farrell; Juan Atilio Gerez; Natalia Cecilia Prymaczok; Merel Kuijs; Maiia Shulman; Anne Hartebrodt; Iryna Prots; Arne Gessner; Friederike Zunke; Jürgen Winkler; David B. Blumenthal; Fabian J. Theis; Roland Riek; Claudia Günther; Markus Neurath; Pooja Gupta; Beate Winner

Journal title: bioRxiv

Journal publisher: bioRxiv

Published year: 2025

DOI identifier: 10.1101/2025.03.25.644826