Periodic Reporting for period 1 - SinMolTermination (Single-molecule visualisation of eukaryotic DNA replication termination to uncover novel mechanisms of replication stress)

Perturbation to the replication of the human genome, so called replication stress, is a key endogenous source of genome instability that leads to ageing, neuropathology and cancer development. DNA replication occurs in three stages: initiation, elongation and termination...